Dissecting serotype-specific contributions to live oral cholera vaccine efficacy

Production of antitoxic immunity by live oral cholera vaccine.

Present knowledge about the extent of antitoxic immunity produced by cholera vaccination is meagre. Kasai and Burrows (J. Infect. Diseases 116:606, 1966) reported that the parenteral injection of killed vaccine increases the antitoxin titer of rabbit sera. They also showed that patients recovering from cholera develop antitoxic activity in their sera. Bhattacharya and Mukerjee (unpublished data...

Stockpiling oral cholera vaccine.

Editorials 714 Cholera is re-emerging as a threat on the global public health stage. The number of reported cases worldwide is back at the peak level observed two decades ago, 1 new Vibrio cholerae strains have appeared and antimicrobial resistance has increased. Weak surveillance systems and the possibility of travel and trade sanctions contribute to widespread underreporting of cholera cases,...

Modified Live Virus Hog Cholera Vaccine--M.L.V

Oral cholera vaccine for traveler's diarrhea prophylaxis.

CLINICAL QUESTION Should the oral cholera vaccine be routinely recommended to prevent traveler's diarrhea (TD)? BOTTOM LINE Randomized controlled trials evaluating oral cholera vaccine for TD did not show a benefit and routine use is not recommended.

High hopes for oral cholera vaccine.

Floods did not deter people from coming for the vaccine. September 2006: phase III of a clinical trial of a bivalent, oral cholera vaccine was under way in a neighbourhood of Kolkata in eastern India. As in any clinical trial, this was a critical stage: the vaccine was being given to large groups of people to confirm its effectiveness, monitor side-effects and collect information that would all...